Modeling of ATM Accumulation and ATM-Mediated Oscillation of p53

A dynamical model to study the accumulation of ATM is proposed in this work. The ATM can accumulate either with low level of DSBs and presence of NBS1 proteins in cells, or with high level of DSBs and absence of NBS1. Both the two ways trigger the cell damage repair system. The interaction in p53 ne...

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Bibliographic Details
Published in2009 3rd International Conference on Bioinformatics and Biomedical Engineering pp. 1 - 4
Main Authors Guo, Zhi-guang, Zhao, Tong-jun, Yuan, Chang-qing, Liu, Hui, Yang, Yue, Yu, Kun, Zeng, Ling-bo, Zhan, Yong
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.06.2009
Subjects
Amino acids
Asynchronous transfer mode
Biophysics
DNA
Feedback loop
Neoplasms
Proteins
Recruitment
Relays
Switches
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Summary:A dynamical model to study the accumulation of ATM is proposed in this work. The ATM can accumulate either with low level of DSBs and presence of NBS1 proteins in cells, or with high level of DSBs and absence of NBS1. Both the two ways trigger the cell damage repair system. The interaction in p53 networks responding to DNA damage is discovered in many researches, but the mechanism of initiating oscillation remains unclear. We examine a model shows that the ATM-NBS1 feedback loop exhibits bistability. The bistability has essential roles in the mechanism of initiate oscillation.
ISBN:9781424429011
1424429013
ISSN:2151-7614
2151-7622
DOI:10.1109/ICBBE.2009.5163075