Leukemia On Chip - Electrical Impedance Spectroscopy As An Online Readout To Investigate Drug-Cancer Interaction
Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) uni...
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Published in | 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) pp. 606 - 608 |
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Main Authors | , , , , , |
Format | Conference Proceeding |
Language | English |
Published |
IEEE
01.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research. |
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ISSN: | 2167-0021 |
DOI: | 10.1109/TRANSDUCERS.2019.8808781 |