Leukemia On Chip - Electrical Impedance Spectroscopy As An Online Readout To Investigate Drug-Cancer Interaction

Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) uni...

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Bibliographic Details
Published in2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) pp. 606 - 608
Main Authors Gokce, Furkan, Ravaynia, Paolo S., Kaestli, Alicia J., Modena, Mario M., Hierlemann, Andreas, Renggli, Kasper
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.06.2019
Subjects
drug efficacy
drug screening
Drugs
Electrical impedance spectroscopy
Electrodes
Impedance
leukemia
Microfluidics
microphysiological systems
Sociology
Spectroscopy
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Summary:Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research.
ISSN:2167-0021
DOI:10.1109/TRANSDUCERS.2019.8808781