Transient electropore lifetimes in skeletal muscle cells

Electroporation of skeletal muscle cell membranes has been postulated to cause myonecrosis in most victims of major electrical trauma. (1,2) To precisely quantify membrane damage due to electroporation, we utilized a ratiometric fluorometric assay to determine the threshold of imposed transmembrane...

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Bibliographic Details
Published in1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 1; pp. 304 - 306
Main Authors Lee, Raphael C., Hammer, Stephanie M., Canaday, Daniel J.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.1992
Subjects
Accidents
Injuries
Permeability
Phasor measurement units
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Summary:Electroporation of skeletal muscle cell membranes has been postulated to cause myonecrosis in most victims of major electrical trauma. (1,2) To precisely quantify membrane damage due to electroporation, we utilized a ratiometric fluorometric assay to determine the threshold of imposed transmembrane potential required to reversibly and irreversibly electroporate the cell membrane and calculated the time constants for electropores created over a wide range of applied fields.
ISBN:0780307852
9780780307858
DOI:10.1109/IEMBS.1992.5760977