Chromatographic chiral separation on chiral stationary phase by HPLC: Cellulose 4-methylbenzoate beads as chiral stationary phase for chiral separation of some racemates by high performance liquid chromatography

The spherical beads were first systhesized by cellulose 4-methylbenzoate with partial hydroxyl groups, which was then crosslinked in the beads with 4, 4'-diphenylmethane dissocyanate. The obtained crosslinked beads were packed into an HPLC column and used as chiral stationary phase (CSP) for ch...

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Bibliographic Details
Published in2011 International Conference on Consumer Electronics, Communications and Networks (CECNet) pp. 4850 - 4853
Main Authors Xiaoqian Han, Dabing Zhang, Wanliang Liu, Hong Cui, Lili An
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.04.2011
Subjects
cellulose tris(4-methylbenzoate) spherical beads
Chemicals
chiral stationary phase
chromatographic chiral separation
Loading
Methanol
Mobile communication
Silicon compounds
Solvents
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Summary:The spherical beads were first systhesized by cellulose 4-methylbenzoate with partial hydroxyl groups, which was then crosslinked in the beads with 4, 4'-diphenylmethane dissocyanate. The obtained crosslinked beads were packed into an HPLC column and used as chiral stationary phase (CSP) for chiral separation of some racemates by high performance liquid chromatography (HPLC) using mobile phases contained with 1-hexane and different alcohols. The influence of the concentration and structure of alcoholic modifiers on separation were investigated. Among the tested racemates, four racemates were first separated on this CSP. The loading capacity of cellulose 4-methylbenzoate beads for racemic Trögger base was investigated.
ISBN:1612844588
9781612844589
DOI:10.1109/CECNET.2011.5768455