Tau reduction prevents disease in a mouse model of Dravet syndrome

• Published in: Annals of neurology Vol. 76; no. 3; pp. 443 - 456
• Main Authors: Gheyara, Ania L., Ponnusamy, Ravikumar, Djukic, Biljana, Craft, Ryan J., Ho, Kaitlyn, Guo, Weikun, Finucane, Mariel M., Sanchez, Pascal E., Mucke, Lennart
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2014; Wiley Subscription Services, Inc
• Subjects: Alleles; Animals; Behavior; Behavior, Animal - physiology; Disease Models, Animal; Electroencephalography; Epilepsies, Myoclonic - metabolism; Epilepsies, Myoclonic - physiopathology; Epilepsies, Myoclonic - therapy; Epilepsy; Female; Hippocampus - metabolism; Hippocampus - pathology; Hippocampus - physiopathology; Learning - physiology; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mortality; Mutation - genetics; NAV1.1 Voltage-Gated Sodium Channel - genetics; Seizures - etiology; Seizures - metabolism; Seizures - physiopathology; tau Proteins - genetics; tau Proteins - metabolism

Objective Reducing levels of the microtubule‐associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as Alzheimer disease. We wanted to determine whether tau reduction may also be of benefit in intractable genetic epilepsies. Met...