Algorithm for Analysis of the Metabolic Activity of the Ex Vivo Perfused Liver

• Published in: 2022 IEEE 23rd International Conference of Young Professionals in Electron Devices and Materials (EDM) pp. 481 - 485
• Main Authors: Shadrin, Konstantin V., Pakhomova, Vera G., Yakovleva, Yuliya A., Kryukova, Olga V., Rupenko, Alexander P.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 30.06.2022
• Subjects: algorithm; Analytical models; Decision support systems; ex vivo perfusion; Hemodynamics; Liver; Mathematical models; metabolism; organ preservation; Organ transplantation; Statistical analysis
• ISSN: 2325-419X
• DOI: 10.1109/EDM55285.2022.9855162

Organ transplantation is one of the most complex methods of radical treatment, which involves the temporary presence of an organ in an isolated state. Ex vivo perfusion allows for diagnostic measures: laboratory analysis, morphological examination, and hemodynamic assessment. There is also a possibility to detect changes at the metabolic level using mathematical modeling. Taking into account the above methods, an algorithm for estimating the metabolic activity of the liver under ex vivo conditions was developed, and a form was created for entering the data necessary for the analysis. The results of the program operation are saved in a separate document with a convenient division into sheets. The proposed method for assessing the activity of a liver graft was successfully tested with the using ex vivo liver perfusion experimental data. The test results include the results of statistical analysis and flow modeling. This algorithm allows one to identify the relationship between the indicators, to determine changes in the levels of markers and to make decisions about their significance. It unifies the actions of researchers during the ex vivo perfusion of an organ. Being a decision support system, the algorithm can simplify, speed up and make the work of researchers and doctors more efficient.