Orthostatic Hypotension in Parkinson Disease: How Much You Fall or How Low You Go?

• Published in: Movement disorders Vol. 30; no. 5; pp. 639 - 645
• Main Authors: Palma, Jose-Alberto, Gomez-Esteban, Juan Carlos, Norcliffe-Kaufmann, Lucy, Martinez, Jose, Tijero, Beatriz, Berganzo, Koldo, Kaufmann, Horacio
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 15.04.2015; Wiley Subscription Services, Inc
• Subjects: Age Factors; Aged; Antiparkinson Agents - therapeutic use; autonomic failure; Blood Pressure - physiology; consensus criteria; dysautonomia; Europe; Female; Humans; Hypotension, Orthostatic - diagnosis; Hypotension, Orthostatic - epidemiology; Levodopa - therapeutic use; Male; mean blood pressure; Middle Aged; Movement disorders; Parkinson Disease - complications; Parkinson Disease - drug therapy; Prospective Studies; Sensitivity and Specificity; Severity of Illness Index; standing blood pressure; supine hypertension; Surveys and Questionnaires; United States; United States; Europe; autonomic failure; supine hypertension; consensus criteria; mean blood pressure; dysautonomia; standing blood pressure
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.26079

ABSTRACT Orthostatic hypotension (OH) is frequent in patients with Parkinson's disease (PD) and can occur with or without symptoms. Pharmacological treatments are effective, but often exacerbate supine hypertension. Guidelines exist for the diagnosis, but not for the treatment of OH. We examined the relationship between blood pressure (BP) and symptoms in a cohort of PD patients with the goal of identifying a hemodynamic target to guide treatment. We measured BP supine and upright (tilt or active standing) and identified the presence or absence of symptomatic OH by using a validated patient‐reported outcome questionnaire in 210 patients with PD. We evaluated the usefulness of the 20/10 and 30/15 mmHg diagnostic criteria (systolic/diastolic) to identify symptomatic OH. Fifty percent of the PD patient cohort met criteria for the 20/10 fall and 30% for the 30/15 BP fall. Among the patients who met either OH criteria, the percentage of those with symptoms was small (33% of those with 20/10 and 44% of those with 30/15 mmHg; 16% and 13%, respectively, overall). Symptomatic OH was associated with an upright mean BP below 75 mmHg. A mean standing BP <75 mmHg had a sensitivity of 97% and a specificity of 98% for detecting symptomatic OH. Although the prevalence of OH in PD is high, not all patients have symptoms of organ hypoperfusion. A mean standing BP below 75 mmHg appears to be a useful benchmark when deciding whether the benefits of initiating pharmacological treatment of OH outweigh the risks of exacerbating supine hypertension. © 2015 International Parkinson and Movement Disorder Society