Methods to enhance laser speckle imaging of high-flow and low-flow vasculature

The objective of this paper is to present two methods to extend the response range of laser speckle imaging (LSI). We report on the use of two methods (image exposure time control and magnetomotive actuation of exogenous contrast agents) to enhance characterization of high- and low-flow vasculature,...

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Published in2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2009; pp. 4073 - 4076
Main Authors Choi, B., Ringold, T.L., Jeehyun Kim
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.01.2009
Subjects
Algorithms
Biomedical imaging
Blood flow
Blood Flow Velocity - physiology
Charge coupled devices
Crystallization
Ferric Compounds - chemistry
Fiber lasers
Humans
Image Interpretation, Computer-Assisted - methods
Imaging phantoms
Instruments
Large scale integration
Lasers
Magnetics
Metal Nanoparticles - chemistry
Nanoparticles
Nanotechnology - methods
Phantoms, Imaging
Regional Blood Flow - physiology
Ring lasers
Speckle
Time Factors
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Summary:The objective of this paper is to present two methods to extend the response range of laser speckle imaging (LSI). We report on the use of two methods (image exposure time control and magnetomotive actuation of exogenous contrast agents) to enhance characterization of high- and low-flow vasculature, respectively. With an exposure time of 10 and 0.01 ms, the linear response range extended to 10 and 280 mm/s, respectively. With application of an AC magnetic field to a solution of stagnant SPIO particles, an apparent increase of ~3times in speckle flow index was induced.
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2009.5333204