Microcapsules with self-microemulsifying core: optimization of shell-forming phase

Microcapsules with self-microemulsifying core were originated by the vibrating nozzle method. Alginate-pectin (A/P) ratio of the shell forming phase was optimized with regard to core phase retention and drug release kinetics from dried microcapsules. Well shaped microcapsules with high encapsulation...

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Bibliographic Details
Published inPharmazie Vol. 65; no. 5; pp. 391 - 392
Main Authors Zvonar, A., Gašperlin, M.
Format Journal Article
LanguageEnglish
Published Germany Govi-Verlag 01.05.2010
Subjects
Capsules - chemistry
Desiccation
Diuretics - administration & dosage
Diuretics - chemistry
Drug Compounding - methods
Emulsions
Excipients
Furosemide - administration & dosage
Furosemide - chemistry
Kinetics
Pectins
Sodium Chloride
Solubility
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Summary:Microcapsules with self-microemulsifying core were originated by the vibrating nozzle method. Alginate-pectin (A/P) ratio of the shell forming phase was optimized with regard to core phase retention and drug release kinetics from dried microcapsules. Well shaped microcapsules with high encapsulation efficiency were produced when an A/P composition of 25:75 was used. Microcapsules with higher pectin content exhibited faster drug release, which was additionally enhanced by the addition of sodium chloride to the shell phase.
Bibliography:0031-7144(20100501)65:5L.391;1-
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ISSN:0031-7144
DOI:10.1691/ph.2010.9395