Serum selenium is low in newly diagnosed Graves' disease: a population-based study
Summary Context Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. Objective To compare serum selenium (s‐Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. Design and settings S...
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| Published in | Clinical endocrinology (Oxford) Vol. 79; no. 4; pp. 584 - 590 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Blackwell Publishing Ltd
01.10.2013
Blackwell Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0300-0664 1365-2265 1365-2265 |
| DOI | 10.1111/cen.12185 |
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| Abstract | Summary
Context
Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.
Objective
To compare serum selenium (s‐Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.
Design and settings
S‐Se was measured in triplicate by a fluorimetric method.
Participants
Patients with newly diagnosed Graves’ disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO‐Ab) (TPO‐Ab > 1500 U/ml, n = 92) and random controls (n = 830).
Main outcome measure
Differences in s‐Se values.
Results
S‐Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s‐Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s‐Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s‐Se between euthyroid participants with high TPO‐Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).
Conclusion
Patients with newly diagnosed GD and AIH had significantly lower s‐Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. |
|---|---|
| AbstractList | Summary
Context
Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.
Objective
To compare serum selenium (s‐Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.
Design and settings
S‐Se was measured in triplicate by a fluorimetric method.
Participants
Patients with newly diagnosed Graves’ disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO‐Ab) (TPO‐Ab > 1500 U/ml, n = 92) and random controls (n = 830).
Main outcome measure
Differences in s‐Se values.
Results
S‐Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s‐Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s‐Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s‐Se between euthyroid participants with high TPO‐Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).
Conclusion
Patients with newly diagnosed GD and AIH had significantly lower s‐Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. Summary Context Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. Objective To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. Design and settings S-Se was measured in triplicate by a fluorimetric method. Participants Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830). Main outcome measure Differences in s-Se values. Results S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 µg/l (18·4); controls: 98·8 µg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 µg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27). Conclusion Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. [PUBLICATION ABSTRACT] Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. S-Se was measured in triplicate by a fluorimetric method. Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830). Differences in s-Se values. S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27). Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.CONTEXTSelenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.OBJECTIVETo compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.S-Se was measured in triplicate by a fluorimetric method.DESIGN AND SETTINGSS-Se was measured in triplicate by a fluorimetric method.Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830).PARTICIPANTSPatients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830).Differences in s-Se values.MAIN OUTCOME MEASUREDifferences in s-Se values.S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).RESULTSS-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.CONCLUSIONPatients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. |
| Author | Schomburg, Lutz Köhrle, Josef Rasmussen, Lone Banke Carlé, Allan Laurberg, Peter Jørgensen, Torben Ovesen, Lars Bülow Pedersen, Inge Knudsen, Nils |
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| Copyright | 2013 John Wiley & Sons Ltd 2014 INIST-CNRS 2013 John Wiley & Sons Ltd. Copyright © 2013 John Wiley & Sons Ltd |
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| Keywords | Endocrinopathy Immunopathology Hyperthyroidism Thyroid diseases Graves disease Autoimmune disease Early stage Serum Selenium Statistical study Endocrinology |
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Journal of Medicine – volume: 133 start-page: 99 year: 1995 end-page: 109 article-title: Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: a possible role in myxoedematous cretinism publication-title: European Journal of Endocrinology – volume: 88 start-page: 25 year: 2002 end-page: 30 article-title: Concentration of selenium in the whole blood and the thyroid tissue of patients with various thyroid diseases publication-title: Biological Trace Element Research – volume: 148 start-page: 309 year: 2003 end-page: 315 article-title: Association of selenium with thyroid volume and echostructure in 35 to 60‐year‐old French adults publication-title: European Journal of Endocrinology – volume: 17 start-page: 609 year: 2007 end-page: 612 article-title: Effects of 12 months treatment with L‐selenomethionine on serum anti‐TPO Levels in Patients with Hashimoto's thyroiditis publication-title: Thyroid – volume: 341 start-page: 55 year: 2004 end-page: 63 article-title: Supplementation with antioxidants in the treatment of Graves′ disease; the effect on glutathione peroxidase activity and concentration of selenium publication-title: Clinica Chimica Acta – volume: 58 start-page: 36 year: 2003 end-page: 42 article-title: Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency publication-title: Clinical Endocrinology – volume: 17 start-page: 902 year: 2012 end-page: 913 article-title: Thyroid function is maintained despite increased oxidative stress in mice lacking selenoprotein biosynthesis in thyroid epithelial cells publication-title: Antioxidants & Redox Signaling – volume: 148 start-page: 389 year: 2003 end-page: 393 article-title: Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis publication-title: European Journal of Endocrinology – volume: 4 start-page: 454 year: 2008 end-page: 460 article-title: Environmental factors and autoimmune thyroiditis publication-title: Nature Clinical Practice Endocrinology & Metabolism |
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Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.
Objective
To compare serum... Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. To compare serum selenium (s-Se) values in... Summary Context Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. Objective To compare serum... Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.CONTEXTSelenium deficiency may play an important... |
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| SubjectTerms | Adult Biological and medical sciences Denmark Endocrinopathies Female Fundamental and applied biological sciences. Psychology Graves Disease - blood Graves Disease - diagnosis Hashimoto Disease - blood Hashimoto Disease - diagnosis Humans Logistic Models Male Medical sciences Middle Aged Multivariate Analysis Non tumoral diseases. Target tissue resistance. Benign neoplasms Population Surveillance - methods Selenium - blood Thyroid Hormones - blood Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune Vertebrates: endocrinology |
| Title | Serum selenium is low in newly diagnosed Graves' disease: a population-based study |
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