Plasma H2S predicts coronary artery lesions in children with Kawasaki disease
Background The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD). Methods A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2S was analyzed at...
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Published in | Pediatrics international Vol. 57; no. 5; pp. 840 - 844 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Blackwell Publishing Ltd
01.10.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Background
The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).
Methods
A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.
Results
Plasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non‐CAL patients. A plasma H2S cut‐off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.
Conclusion
Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children. |
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Bibliography: | National Natural Science Foundation of China - No. 30901620 and 81121061 Beijing Scientific Research and Technology Project - No. Z131100006813024 ark:/67375/WNG-96BGXBFC-N Major Basic Research Project of China - No. 2011CB503904 and 2012BA103B03 istex:3F41D1F398EB14252DD8FC62402B680FFFDEB7F5 ArticleID:PED12631 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1328-8067 1442-200X |
DOI: | 10.1111/ped.12631 |