Tuberculoma of the brain: a series of 16 cases treated with anti-tuberculosis drugs
OBJECTIVES: To describe the clinical presentation, radiological findings and outcome of treatment with anti-tuberculosis drugs in 16 cases of intracranial tuberculoma.DESIGN: Consecutive cases admitted with tuberculoma to the National Center for Neurological Diseases in Khartoum, Sudan, were include...
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Published in | The international journal of tuberculosis and lung disease Vol. 11; no. 1; pp. 91 - 95 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Paris, France
IUATLD
01.01.2007
Union internationale contre la tuberculose et les maladies respiratoires |
Subjects | |
Online Access | Get full text |
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Summary: | OBJECTIVES: To describe the clinical presentation, radiological findings and outcome of treatment with anti-tuberculosis drugs in 16 cases of intracranial tuberculoma.DESIGN: Consecutive cases admitted with tuberculoma to the National Center for Neurological Diseases in Khartoum,
Sudan, were included in the study. The diagnosis was based on clinical and neuro-imaging features and response to anti-tuberculosis treatment. Histopathology of material from the brain or other extracranial tissues was available in seven cases.RESULTS AND CONCLUSIONS: The commonest presenting
features were headache (100%), generalized convulsions (68.7%) and hemiparesis (56.2%). Computerised axial tomography/magnetic resonance imaging (CT/MRI) showed single or multiple lesions that showed intense contrast enhancement and perilesional edema. The lesions completely cleared on anti-tuberculosis
treatment in the majority of survivors (13/15). Partial clearance of lesion was associated with late presentation, multiple large lesions and advanced miliary disease. We advocate early empirical trial of anti-tuberculosis drugs for intracranial tuberculoma even after a presumptive diagnosis,
particularly in areas where the infection is endemic. |
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Bibliography: | (R) Medicine - General 1027-3719(20070101)11:1L.91;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1027-3719 1815-7920 |