Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates

• Published in: The international journal of tuberculosis and lung disease Vol. 9; no. 2; pp. 216 - 219
• Main Authors: PRAMMANANAN, T, ARJRATANAKOOL, W, CHAIPRASERT, A, TINGTOY, N, LEECHAWENGWONG, M, ASAWAPOKEE, N, LEELARASAMEE, A, DHIRAPUTRA, C
• Format: Journal Article
• Language: English
• Published: Paris, France IUATLD 01.02.2005; Union internationale contre la tuberculose et les maladies respiratoires
• Subjects: Amikacin - pharmacology; Aminosalicylic Acid - pharmacology; Bacterial diseases; Biological and medical sciences; Ciprofloxacin - pharmacology; Drug Resistance, Multiple, Bacterial; Ethionamide - pharmacology; Human bacterial diseases; Human immunodeficiency virus; Infectious diseases; Kanamycin - pharmacology; Mdr-Tb; Medical sciences; Microbial Sensitivity Tests - methods; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Ofloxacin - pharmacology; Second-Line Drugs; Susceptibility; Thailand; Tuberculosis and atypical mycobacterial infections; Thailand; Asia; susceptibility; Drug susceptibility test; Pathogenesis; Mycobacterial infection; Genetic determinism; Multiple resistance; Bacteria; Antituberculous agent; second-line drugs; Public health; Human; Drug; Respiratory disease; MDR-TB; Infection; Chemotherapy; Treatment; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Isolate; Actinomycetes; Antibacterial agent
• ISSN: 1027-3719; 1815-7920

The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing and is exacerbated by the human immunodeficiency virus (HIV) epidemic. The standard short-course regimen used for the treatment of tuberculosis is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing (DST) is necessary to select an appropriate treatment regimen. In this study, DST of 99 MDR-TB strains isolated in Thailand was performed using a drug-impregnated disc method. The results showed that 94.95% of the strains were susceptible to amikacin and kanamycin, 90.91% to ciprofloxacin and ofloxacin, 85.86% to para-aminosalicylic acid, and 78.79% to ethionamide.