Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves

A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model...

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Published in2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2011; pp. 4677 - 4680
Main Authors Hoang-Trong Minh Tuan, Williams, G. S. B., Chikando, A. C., Sobie, E. A., Lederer, W. J., Jafri, M. S.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.01.2011
Subjects
Animals
Calcium
Calcium - metabolism
Computational modeling
Graphics processing unit
Heart Ventricles - cytology
Heart Ventricles - metabolism
Mathematical model
Models, Theoretical
Rats
Sparks
Stochastic Processes
Strontium
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Summary:A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
Bibliography:these authors contributed equally to the work
ISBN:9781424441211
1424441218
ISSN:1094-687X
1557-170X
1558-4615
2694-0604
DOI:10.1109/IEMBS.2011.6091158