hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn
We have previously isolated a protein from mouse liver nuclei that specifically binds to single stranded (TTAGGG)n repeats. TTAGGG is the telomeric repeats of mammals and we therefore named the new protein single stranded telomere binding protein (sTBP). Further studies now identify sTBP as heteroge...
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Published in | Nucleic acids research Vol. 20; no. 24; pp. 6461 - 6464 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
25.12.1992
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Subjects | |
Online Access | Get full text |
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Summary: | We have previously isolated a protein from mouse liver nuclei that specifically binds to single stranded (TTAGGG)n repeats. TTAGGG is the telomeric repeats of mammals and we therefore named the new protein single stranded telomere binding protein (sTBP). Further studies now identify sTBP as heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 on the basis of amino acid sequence determination and antibody reactivity. A2 and B1 form a major part of the protein component of hnRNP particles and are abundant nuclear proteins. Unexpectedly, A2/B1 has a high specificity for binding to the RNA equivalent of TTAGGG, UUAGGG, but under the same conditions does not appear to have a strong affinity for a number of other RNA species. |
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Bibliography: | ArticleID:20.24.6461 To whom correspondence should be addressed ark:/67375/HXZ-1PVRCVH0-F istex:C9278DC36FAD2B3368A69E6FB90BD5DF4D3AC7A3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0305-1048 1362-4962 |
DOI: | 10.1093/nar/20.24.6461 |