Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms
Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu‐opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the...
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| Published in | Alcoholism, clinical and experimental research Vol. 36; no. 7; pp. 1230 - 1236 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, NJ
Blackwell Publishing Ltd
01.07.2012
Wiley |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu‐opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism.
Methods
We investigated a total number of 1,845 alcohol‐dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu‐opioid receptor (OPRM1) polymorphism using chi‐square statistics.
Results
An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co‐dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM‐IV criterion “efforts to cut down or could not” (p = 0.047) was found, but this did not remain significant after the correction for multiple testing.
Conclusions
The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant. |
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| AbstractList | Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism.
We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics.
An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion "efforts to cut down or could not" (p = 0.047) was found, but this did not remain significant after the correction for multiple testing.
The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant. Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics. An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion "efforts to cut down or could not" (p = 0.047) was found, but this did not remain significant after the correction for multiple testing. The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant. Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism.BACKGROUNDSeveral lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism.We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics.METHODSWe investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics.An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion "efforts to cut down or could not" (p = 0.047) was found, but this did not remain significant after the correction for multiple testing.RESULTSAn association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion "efforts to cut down or could not" (p = 0.047) was found, but this did not remain significant after the correction for multiple testing.The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant.CONCLUSIONSThe results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant. Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu‐opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol‐dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu‐opioid receptor (OPRM1) polymorphism using chi‐square statistics. Results An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co‐dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM‐IV criterion “efforts to cut down or could not” (p = 0.047) was found, but this did not remain significant after the correction for multiple testing. Conclusions The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant. |
| Author | Koller, Gabriele Bondy, Brigitta Zill, Peter Preuss, Ulrich W. Soyka, Michael Fehr, Christoph Wodarz, Norbert Ridinger, Monika Rujescu, Dan Pogarell, Oliver |
| Author_xml | – sequence: 1 givenname: Gabriele surname: Koller fullname: Koller, Gabriele email: gabi.koller@med.uni-muenchen.de organization: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany – sequence: 2 givenname: Peter surname: Zill fullname: Zill, Peter organization: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany – sequence: 3 givenname: Dan surname: Rujescu fullname: Rujescu, Dan organization: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany – sequence: 4 givenname: Monika surname: Ridinger fullname: Ridinger, Monika organization: Department of Psychiatry, Psychosomatics and Psychotherapy, University Medical Center, Regensburg, Germany – sequence: 5 givenname: Oliver surname: Pogarell fullname: Pogarell, Oliver organization: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany – sequence: 6 givenname: Christoph surname: Fehr fullname: Fehr, Christoph organization: Department of Psychiatry, Johannes-Gutenberg University, Mainz, Germany – sequence: 7 givenname: Norbert surname: Wodarz fullname: Wodarz, Norbert organization: Department of Psychiatry, Psychosomatics and Psychotherapy, University Medical Center, Regensburg, Germany – sequence: 8 givenname: Brigitta surname: Bondy fullname: Bondy, Brigitta organization: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany – sequence: 9 givenname: Michael surname: Soyka fullname: Soyka, Michael organization: Privatklinik Meiringen, Meiringen, Switzerland – sequence: 10 givenname: Ulrich W. surname: Preuss fullname: Preuss, Ulrich W. organization: Department of Psychiatry, Psychotherapy, Psychosomatics, Martin-Luther-University, Halle, Germany |
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| Keywords | Genetic variability Ethanol Alcoholism Opioid receptor Genotype Genetic parameter Alcohol Variance Alcoholic beverage Symptomatology Association Treatment Dependence Genetics Locus Polymorphism |
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Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol... Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD)... |
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| SubjectTerms | Addictive behaviors Adult Adult and adolescent clinical studies Alcohol Alcoholism Alcoholism - epidemiology Alcoholism - genetics Alcoholism and acute alcohol poisoning Biological and medical sciences Dependence Female Genetic Association Studies - methods Genetic Loci - genetics Genetic Variation - genetics Genetics Humans Male Medical sciences Middle Aged Opioid Receptor Polymorphism Population Surveillance Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Opioid, mu - genetics Toxicology Treatment Outcome |
| Title | Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms |
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