Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms

• Published in: Alcoholism, clinical and experimental research Vol. 36; no. 7; pp. 1230 - 1236
• Main Authors: Koller, Gabriele, Zill, Peter, Rujescu, Dan, Ridinger, Monika, Pogarell, Oliver, Fehr, Christoph, Wodarz, Norbert, Bondy, Brigitta, Soyka, Michael, Preuss, Ulrich W.
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01.07.2012; Wiley
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcohol; Alcoholism; Alcoholism - epidemiology; Alcoholism - genetics; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Dependence; Female; Genetic Association Studies - methods; Genetic Loci - genetics; Genetic Variation - genetics; Genetics; Humans; Male; Medical sciences; Middle Aged; Opioid Receptor; Polymorphism; Population Surveillance; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Opioid, mu - genetics; Toxicology; Treatment Outcome; Genetic variability; Ethanol; Alcoholism; Opioid receptor; Genotype; Genetic parameter; Alcohol; Variance; Alcoholic beverage; Symptomatology; Association; Treatment; Dependence; Genetics; Locus; Polymorphism
• ISSN: 0145-6008; 1530-0277; 1530-0277
• DOI: 10.1111/j.1530-0277.2011.01714.x

Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu‐opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol‐dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu‐opioid receptor (OPRM1) polymorphism using chi‐square statistics. Results An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co‐dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM‐IV criterion “efforts to cut down or could not” (p = 0.047) was found, but this did not remain significant after the correction for multiple testing. Conclusions The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant.