Association between genetic variants in NOD2, C13orf31, and CCDC122 genes and leprosy among the Chinese Yi population

• Published in: International journal of dermatology Vol. 55; no. 1; pp. 65 - 69
• Main Authors: Xiong, Jun-Hao, Mao, Chong, Sha, Xiao-Wei, Jin, Zheng, Wang, Hao, Liu, Yang-Ying, Ning, Yong
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2016
• Subjects: Adult; Age Factors; Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; China - epidemiology; Confidence Intervals; Female; Genetic Predisposition to Disease - epidemiology; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Incidence; Leprosy - ethnology; Leprosy - genetics; Leprosy - physiopathology; Male; Middle Aged; Nod2 Signaling Adaptor Protein - genetics; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Young Adult
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/ijd.12981

Background A significant association between single nucleotide polymorphisms in NOD2, C13orf31, and CCDC122 genes and leprosy has been reported in a previous genome‐wide association study of leprosy in the Chinese Han population. However, it remains unknown whether this association exists among the Chinese Yi population. The aim of this study was to investigate whether single nucleotide polymorphisms in NOD2, C13orf31, and CCDC122 genes are associated with leprosy among the Chinese Yi population in China. Methods We genotyped rs9302752, rs7194886, rs8057341, and rs3135499 in the NOD2 gene; rs3764147 and rs10507522 in the C13orf31 gene; and rs3088362 and rs9533634 in the CCDC122 gene in a Chinese Yi cohort comprised of 319 patients with leprosy and 355 ethnic‐matched controls. The differences between the patients and healthy controls were analyzed using chi‐squared analysis. Results Significant differences of rs3135499 in NOD2, rs3764147 and rs10507522 in C13orf31, and rs3088362 and rs9533634 in CCDC122 were observed between the patients and the healthy control groups in the cohort. The allelic P values and odd ratios were as follows: rs3135499, 1.0 × 10−8 and 2.55; rs3764147, 1.7 × 10−7 and 1.88; rs10507522, 1.16 × 10−5 and 1.95; rs3088362, 8.2 × 10−4 and 1.51; rs9533634, 5.34 × 10−5 and 1.73. No significant differences were found in the distributions of rs9302752, rs7194886, and rs8057341 between the patients and healthy controls. Conclusions We demonstrated that genetic variants in the NOD2, C13orf31, and CCDC122 genes are closely associated with leprosy among the Chinese Yi population, which implicates the pathogenic role of NOD2, C13orf31, and CCDC122 genes in a different ethnicity.