Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model
Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the ‘extrinsic’ aspects. Here, we show that skin f...
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| Published in | Experimental dermatology Vol. 22; no. 1; pp. 62 - 64 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Denmark
Blackwell Publishing Ltd
01.01.2013
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| Abstract | Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the ‘extrinsic’ aspects. Here, we show that skin from old SAMP1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants. |
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| AbstractList | Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet-irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the 'extrinsic' aspects. Here, we show that skin from old SAMP1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants. |
| Author | Takeuchi, Minoru Kamiya, Emi Kawamura, Noriko Hosokawa, Masanori Furukawa, Ayako Niwa, Masanao Chiba, Yoichi Sakura, Masaaki |
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| Notes | ArticleID:EXD12059 ark:/67375/WNG-02C62Z1R-S istex:13161701211D5F95FB2777067991B279ECEB68E5 Figure S1. Expression changes of photoaging-related molecules in the skin from SAMP1 and SAMR1 mice.Figure S2. Age-associated changes in the TBARS levels in the skin from SAMP1 and SAMR1 mice.Table S1. Changes in mRNA expression in the dorsal skin from old SAMP1 mice and human photoaged skin.Data S1. Materials and methods and supplementary results. SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
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| Snippet | Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated... Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet-irradiated... |
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| SubjectTerms | Animals Gene Expression Interferon-gamma - genetics Interleukin-1beta - genetics Interleukin-6 - genetics Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 7 - genetics Mice Models, Animal Nitric Oxide Synthase Type II - genetics Oxidative Stress Phenotype photoageing RNA, Messenger - metabolism senescence-accelerated mouse Skin Aging - genetics Skin Aging - pathology Skin Aging - physiology Thiobarbituric Acid Reactive Substances - metabolism Transforming Growth Factor beta1 - genetics Tumor Necrosis Factor-alpha - genetics |
| Title | Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model |
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