Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model

Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the ‘extrinsic’ aspects. Here, we show that skin f...

Full description

Saved in:
Bibliographic Details
Published inExperimental dermatology Vol. 22; no. 1; pp. 62 - 64
Main Authors Sakura, Masaaki, Chiba, Yoichi, Kamiya, Emi, Furukawa, Ayako, Kawamura, Noriko, Niwa, Masanao, Takeuchi, Minoru, Hosokawa, Masanori
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.01.2013
Subjects
Animals
Gene Expression
Interferon-gamma - genetics
Interleukin-1beta - genetics
Interleukin-6 - genetics
Matrix Metalloproteinase 12 - genetics
Matrix Metalloproteinase 7 - genetics
Mice
Models, Animal
Nitric Oxide Synthase Type II - genetics
Oxidative Stress
Phenotype
photoageing
RNA, Messenger - metabolism
senescence-accelerated mouse
Skin Aging - genetics
Skin Aging - pathology
Skin Aging - physiology
Thiobarbituric Acid Reactive Substances - metabolism
Transforming Growth Factor beta1 - genetics
Tumor Necrosis Factor-alpha - genetics
Online AccessGet full text

Cover

More Information
Summary:Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the ‘extrinsic’ aspects. Here, we show that skin from old SAMP1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants.
Bibliography:ArticleID:EXD12059
ark:/67375/WNG-02C62Z1R-S
istex:13161701211D5F95FB2777067991B279ECEB68E5
Figure S1. Expression changes of photoaging-related molecules in the skin from SAMP1 and SAMR1 mice.Figure S2. Age-associated changes in the TBARS levels in the skin from SAMP1 and SAMR1 mice.Table S1. Changes in mRNA expression in the dorsal skin from old SAMP1 mice and human photoaged skin.Data S1. Materials and methods and supplementary results.
SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12059