Expression of extracellular matrix metalloproteinase inducer glycosylation and caveolin-1 in healthy and inflamed human gingiva
Background and Objective Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin‐1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin‐1 expression in healt...
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| Published in | Journal of periodontal research Vol. 49; no. 2; pp. 197 - 204 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.04.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3484 1600-0765 1600-0765 |
| DOI | 10.1111/jre.12095 |
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| Abstract | Background and Objective
Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin‐1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin‐1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin‐1 expression, and assessed how this interaction influenced MMP‐1 production.
Material and Methods
Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin‐1 and MMP‐1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin‐1 co‐localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin‐1, active MMP‐1 and proMMP‐1 expression was assessed by Western blot.
Results
EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast‐like cells. Strong caveolin‐1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin‐1 co‐localization in gingival epithelium, endothelial and fibroblast‐like cells. Compared with healthy subjects, the chronic periodontitis group had increased high‐glycoform EMMPRIN (HG‐EMMPRIN) and active MMP‐1 expression (p < 0.05). Active MMP‐1 and proMMP‐1 protein levels were positively correlated with HG‐EMMPRIN levels (p < 0.05).
Conclusion
EMMPRIN and caveolin‐1 colocalize in periodontal tissues. The increased active MMP‐1 and proMMP‐1 production may be associated with elevated HG‐EMMPRIN levels. |
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| AbstractList | Background and Objective
Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin‐1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin‐1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin‐1 expression, and assessed how this interaction influenced MMP‐1 production.
Material and Methods
Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin‐1 and MMP‐1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin‐1 co‐localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin‐1, active MMP‐1 and proMMP‐1 expression was assessed by Western blot.
Results
EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast‐like cells. Strong caveolin‐1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin‐1 co‐localization in gingival epithelium, endothelial and fibroblast‐like cells. Compared with healthy subjects, the chronic periodontitis group had increased high‐glycoform EMMPRIN (HG‐EMMPRIN) and active MMP‐1 expression (p < 0.05). Active MMP‐1 and proMMP‐1 protein levels were positively correlated with HG‐EMMPRIN levels (p < 0.05).
Conclusion
EMMPRIN and caveolin‐1 colocalize in periodontal tissues. The increased active MMP‐1 and proMMP‐1 production may be associated with elevated HG‐EMMPRIN levels. Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin-1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin-1 expression, and assessed how this interaction influenced MMP-1 production. Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin-1 and MMP-1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin-1 co-localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin-1, active MMP-1 and proMMP-1 expression was assessed by Western blot. EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast-like cells. Strong caveolin-1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin-1 co-localization in gingival epithelium, endothelial and fibroblast-like cells. Compared with healthy subjects, the chronic periodontitis group had increased high-glycoform EMMPRIN (HG-EMMPRIN) and active MMP-1 expression (p < 0.05). Active MMP-1 and proMMP-1 protein levels were positively correlated with HG-EMMPRIN levels (p < 0.05). EMMPRIN and caveolin-1 colocalize in periodontal tissues. The increased active MMP-1 and proMMP-1 production may be associated with elevated HG-EMMPRIN levels. Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin-1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin-1 expression, and assessed how this interaction influenced MMP-1 production.BACKGROUND AND OBJECTIVEGlycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin-1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin-1 expression, and assessed how this interaction influenced MMP-1 production.Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin-1 and MMP-1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin-1 co-localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin-1, active MMP-1 and proMMP-1 expression was assessed by Western blot.MATERIAL AND METHODSGingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin-1 and MMP-1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin-1 co-localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin-1, active MMP-1 and proMMP-1 expression was assessed by Western blot.EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast-like cells. Strong caveolin-1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin-1 co-localization in gingival epithelium, endothelial and fibroblast-like cells. Compared with healthy subjects, the chronic periodontitis group had increased high-glycoform EMMPRIN (HG-EMMPRIN) and active MMP-1 expression (p < 0.05). Active MMP-1 and proMMP-1 protein levels were positively correlated with HG-EMMPRIN levels (p < 0.05).RESULTSEMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast-like cells. Strong caveolin-1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin-1 co-localization in gingival epithelium, endothelial and fibroblast-like cells. Compared with healthy subjects, the chronic periodontitis group had increased high-glycoform EMMPRIN (HG-EMMPRIN) and active MMP-1 expression (p < 0.05). Active MMP-1 and proMMP-1 protein levels were positively correlated with HG-EMMPRIN levels (p < 0.05).EMMPRIN and caveolin-1 colocalize in periodontal tissues. The increased active MMP-1 and proMMP-1 production may be associated with elevated HG-EMMPRIN levels.CONCLUSIONEMMPRIN and caveolin-1 colocalize in periodontal tissues. The increased active MMP-1 and proMMP-1 production may be associated with elevated HG-EMMPRIN levels. Background and Objective Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its ability to induce matrix metalloproteinases (MMPs) production. This study investigated EMMPRIN glycosylation and caveolin-1 expression in healthy and inflamed human gingival tissues, analyzed the relationship between EMMPRIN glycosylation and caveolin-1 expression, and assessed how this interaction influenced MMP-1 production. Material and Methods Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (chronic periodontitis) subjects. EMMPRIN, caveolin-1 and MMP-1 expressions were analyzed by immunohistochemistry. EMMPRIN and caveolin-1 co-localization was detected by immunofluorescence. EMMPRIN glycosylation, caveolin-1, active MMP-1 and proMMP-1 expression was assessed by Western blot. Results EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast-like cells. Strong caveolin-1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin-1 co-localization in gingival epithelium, endothelial and fibroblast-like cells. Compared with healthy subjects, the chronic periodontitis group had increased high-glycoform EMMPRIN (HG-EMMPRIN) and active MMP-1 expression (p < 0.05). Active MMP-1 and proMMP-1 protein levels were positively correlated with HG-EMMPRIN levels (p < 0.05). Conclusion EMMPRIN and caveolin-1 colocalize in periodontal tissues. The increased active MMP-1 and proMMP-1 production may be associated with elevated HG-EMMPRIN levels. |
| Author | Li, C. Xiang, J. Wang, J. Yang, D. Shang, S. |
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| Keywords | Caveolin-1 EMMPRIN glycosylation MMP-1 periodontitis |
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| References_xml | – reference: Knauper V, Lopez-Otin C, Smith B, Knight G, Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem 1996;271:1544-1550. – reference: Mazza JE, Newman MG, Sims TN. Clinical and antimicrobial effect of stannous fluoride on periodontitis. J Clin Periodontol 1981;8:203-212. – reference: Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135. – reference: Iacono KT, Brown AL, Greene MI, Saouaf SJ. CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol 2007;83:283-295. – reference: Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6. – reference: Narayanan AS, Page RC. Connective tissues of the periodontium: a summary of current work. Coll Relat Res 1983;3:33-64. – reference: Kasinrerk W, Tokrasinwit N, Phunpae P. 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null mice are viable but show evidence of hyperproliferative and vascular abnormalities publication-title: J Biol Chem – volume: 26 start-page: 819 year: 2012 end-page: 832 article-title: Bile acids down‐regulate caveolin‐1 in esophageal epithelial cells through sterol responsive element‐binding protein publication-title: Mol Endocrinol – volume: 74 start-page: 188 year: 2003 end-page: 195 article-title: Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy and diseased human gingiva publication-title: J Periodontol – volume: 298 start-page: L775 year: 2010 end-page: L783 article-title: A role for caveolin‐1 in mechanotransduction of fetal type II epithelial cells publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 29 start-page: 267 year: 2008 end-page: 276 article-title: A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa publication-title: Hum Mutat – volume: 68 start-page: 673 year: 1992 end-page: 682 article-title: Caveolin, a protein component of caveolae membrane coats publication-title: Cell – volume: 96 start-page: 184 year: 1999 end-page: 192 article-title: CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA‐1/ICAM‐1 pathway publication-title: Immunology – volume: 272 start-page: 24 year: 1997 end-page: 27 article-title: Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells publication-title: J Biol Chem – volume: 64 start-page: 210 year: 2011 end-page: 216 article-title: Caveolin‐1 is a negative regulator of MMP‐1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway publication-title: J Dermatol Sci – volume: 83 start-page: 283 year: 2007 end-page: 295 article-title: CD147 immunoglobulin superfamily receptor function and role in pathology publication-title: Exp Mol Pathol |
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Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin‐1 and influences its... Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its ability to induce matrix... Background and Objective Glycosylated extracellular matrix metalloproteinase inducer (EMMPRIN) is specifically associated with caveolin-1 and influences its... |
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| SubjectTerms | Adolescent Adult Basigin - analysis Caveolin 1 - analysis Caveolin-1 Chronic Periodontitis - metabolism Chronic Periodontitis - pathology Dental Plaque Index EMMPRIN Endothelial Cells - chemistry Endothelium, Vascular - chemistry Epithelial Cells - chemistry Female Fibroblasts - chemistry Gingiva - chemistry Gingiva - cytology Glycosylation Humans Male Matrix Metalloproteinase 1 - analysis Middle Aged MMP-1 Periodontal Attachment Loss - classification Periodontal Index Periodontal Pocket - classification periodontitis Young Adult |
| Title | Expression of extracellular matrix metalloproteinase inducer glycosylation and caveolin-1 in healthy and inflamed human gingiva |
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