Genetic association study between alpha 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

• Published in: American journal of medical genetics Vol. 96; no. 2; p. 133
• Main Authors: Tang, G, Jiang, S, Zhang, M, Lin, S, Qian, Y, Wu, X, Wang, D, Jin, T, Gu, N
• Format: Journal Article
• Language: English
• Published: United States 03.04.2000
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; alpha 1-Antichymotrypsin - genetics; Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Apolipoproteins E - genetics; Asian Continental Ancestry Group; China - epidemiology; Female; Gene Frequency; Humans; Male; Middle Aged; Polymorphism, Genetic - genetics; Serine Proteinase Inhibitors - genetics; China

We investigated a common signal peptide polymorphism in the alpha 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and...