Genetic association study between alpha 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

We investigated a common signal peptide polymorphism in the alpha 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and...

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Bibliographic Details
Published inAmerican journal of medical genetics Vol. 96; no. 2; p. 133
Main Authors Tang, G, Jiang, S, Zhang, M, Lin, S, Qian, Y, Wu, X, Wang, D, Jin, T, Gu, N
Format Journal Article
LanguageEnglish
Published United States 03.04.2000
Subjects
Adult
Aged
Aged, 80 and over
Alleles
alpha 1-Antichymotrypsin - genetics
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Apolipoproteins E - genetics
Asian Continental Ancestry Group
China - epidemiology
Female
Gene Frequency
Humans
Male
Middle Aged
Polymorphism, Genetic - genetics
Serine Proteinase Inhibitors - genetics
China
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Summary:We investigated a common signal peptide polymorphism in the alpha 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Han population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:133-135, 2000.
ISSN:0148-7299
DOI:10.1002/(SICI)1096-8628(20000403)96:2<133::AID-AJMG1>3.0.CO;2-Y