Growth patterns of Chinese patients with Prader-Willi syndrome
The aim of the present study was to investigate the spontaneous development of growth and weight gain of patients with Prader‐Willi syndrome (PWS) in Mainland China. We retrospectively analyzed 120 cases of PWS diagnosed from 1994 to 2014 in Mainland China. Scatter diagram of the growth data was com...
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Published in | Congenital anomalies Vol. 55; no. 4; pp. 173 - 177 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English Japanese |
Published |
Australia
Blackwell Publishing Ltd
01.11.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of the present study was to investigate the spontaneous development of growth and weight gain of patients with Prader‐Willi syndrome (PWS) in Mainland China. We retrospectively analyzed 120 cases of PWS diagnosed from 1994 to 2014 in Mainland China. Scatter diagram of the growth data was compared to standardized growth curve. The length at birth was similar to the normal population and the mean birthweight is under the 50th centile of normal population. Heights in 43% (27/62) of patients had dropped off below the 3rd centile of their peers after 5 years of age. Weights in 65.9% (58/88) of patients had exceeded the 97th centile of their peers after 3 years of age. Early obesity is obvious in 92.9% (66/71) of patients with body mass index (BMI) up the 97th centile of their peers from 2–3 years of age. Final mean height is 149.3 ± 11.2 cm for females (n = 7) and 146.2 ± 9.8 cm for males (n = 6), showing 11.3 cm and 26.6 cm below the average height for normal Chinese girls and boys. The growth pattern of PWS in Mainland China is comparable to those in Caucasians. Early intervention with recombinant human growth hormone is warranted considering the early onset of growth retardation and obesity. |
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Bibliography: | Beijing Natural Science Foundation - No. 7122146 ark:/67375/WNG-3PNJ3SWD-K istex:345A170E0BD3E355BB006F41A970C6C2D5654B69 ArticleID:CGA12111 National Key Program of Clinical Science - No. WBYZ2011-873 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0914-3505 1741-4520 |
DOI: | 10.1111/cga.12111 |