Cytotoxic Cyclic Norterpene Peroxides from a Red Sea Sponge Diacarnus erythraenus

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 10; pp. 1332 - 1335
• Main Authors: YOUSSEF, Diaa T. A., YOSHIDA, Wesley Y., KELLY, Michelle, SCHEUER, Paul J.
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.10.2001; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: aikupikoxide A; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Chromatography, High Pressure Liquid; Colonic Neoplasms; cyclic norterpene peroxides; Diacarnus erythraenus; Drug Screening Assays, Antitumor; Egypt; General pharmacology; Humans; Indian Ocean; Inhibitory Concentration 50; Leukemia P388; Life Sciences & Biomedicine; Lung Neoplasms; Magnetic Resonance Spectroscopy; Marine; Medical sciences; Mice; Molecular Structure; natural products; O-methyl guaianediol; Peroxides - chemistry; Peroxides - isolation & purification; Peroxides - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Porifera - chemistry; Science & Technology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Stereoisomerism; Terpenes - chemistry; Terpenes - isolation & purification; Terpenes - pharmacology; Tumor Cells, Cultured - drug effects; Red Sea; Indian Ocean; Egypt; ISW, Red Sea; NORDITERPENE; CHEMISTRY; DITERPENOIDS; MARINE SPONGE; Antineoplastic agent; Lymphoid cell; Lung; Cytotoxicity; Oxygen heterocycle; Marine environment; Ester; Carboxylic acid; Tertiary alcohol; Colon; Tumor cell; Human; Terpenoid; Aliphatic compound; Pharmacognosy; Rodentia; Animal origin; Diketone; In vitro; Biological activity; Vertebrata; Mammalia; Cell line; Mouse; Porifera; Animal; Diterpene; Isolation; Invertebrata; Enone; Sesterterpenes; Organic peroxide; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np010184a

Investigation of the lipophilic extract of the Red Sea sponge Diacarnus erythraenus revealed one new norsesterterpene cyclic peroxide, aikupikoxide A (1), three new norditerpene cyclic peroxides, aikupikoxide B-D (2-4), and the known norterpene peroxides muqubilin and nuapapuin A methyl ester. In addition, a new sesquiterpene, O-methyl guaianediol, was isolated. Their structures were determined by means of spectroscopic methods. The cytotoxic activities for the isolated compounds have been reported.