Preparation and Characterization of a pH- and Thermally Responsive Poly(N-isopropylacrylamide-co-acrylic acid)/Porous SiO2 Hybrid

• Published in: Advanced functional materials Vol. 20; no. 5; pp. 826 - 833
• Main Authors: Perelman, Loren A., Moore, Troy, Singelyn, Jennifer, Sailor, Michael J., Segal, Ester
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 09.03.2010; WILEY‐VCH Verlag
• Subjects: biosensors; hybrid materials; hydrogels; nanocomposites; porous silicon; sensors
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.200900822

A multifunctional nanohybrid composed of a pH‐ and thermoresponsive hydrogel, poly(N‐isopropylacrylamide‐co‐acrylic acid) [poly(NIPAM‐co‐AAc)], is synthesized in situ within the mesopores of an oxidized porous Si template. The hybrid is characterized by electron microscopy and by thin film optical interference spectroscopy. The optical reflectivity spectrum of the hybrid displays Fabry–Pérot fringes characteristic of thin film optical interference, enabling direct, real‐time observation of the pH‐induced swelling, and volume phase transitions associated with the confined poly(NIPAM‐co‐AAc) hydrogel. The optical response correlates to the percentage of AAc contained within the hydrogel, with a maximum change observed for samples containing 20% AAc. The swelling kinetics of the hydrogel are significantly altered due to the nanoscale confinement, displaying a more rapid response to pH or heating stimuli relative to bulk polymer films. The inclusion of AAc dramatically alters the thermoresponsiveness of the hybrid at pH 7, effectively eliminating the lower critical solution temperature (LCST). The observed changes in the optical reflectivity spectrum are interpreted in terms of changes in the dielectric composition and morphology of the hybrids. Thin film optical interference is used to investigate pH‐ and thermally triggered volume phase transitions in a hybrid thin film consisting of a nanostructured porous SiO2 host with a polymeric hydrogel guest. The nanoconfined hydrogel responds to the stimuli much more quickly than a bulk film.