Dextrans - potential polymeric drug carriers for flurbiprofen
Dextrans have been used as carrier for flurbiprofen. Conjugates of flurbiprofen were synthesized by preparing their acylimidazol derivatives which were condensed in situ with dextrans of different molecular weight (40000, 60000, 110000 and 200000). The structures of the synthesized conjugates were c...
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Published in | Pharmazie Vol. 58; no. 6; pp. 389 - 391 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Eschborn
Govi-Verlag
01.06.2003
Govi |
Subjects | |
Online Access | Get full text |
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Summary: | Dextrans have been used as carrier for flurbiprofen. Conjugates of flurbiprofen were synthesized by preparing their acylimidazol derivatives which were condensed in situ with dextrans of different molecular weight (40000, 60000, 110000 and 200000). The structures of the synthesized
conjugates were confirmed by IR and NMR spectroscopy. The degrees of substitution were obtained between 8.0 to 9.5% and molecular weight was determined by Mark-Howin Sakurada viscosity equation. A hydrolysis study was performed in different buffer solutions (pH 1.2, 7.4, 9.0) and 80%
human plasma (pH 7.4). The hydrolysis followed first order kinetics. Much faster hydrolysis was observed at pH 9.0 compared to buffer solution pH 7.4 and 80% human plasma (pH 7.4). The biological evaluation for acute and chronic anti-inflammatory activity was performed and the results
were found to be comparable with the parent drug. The conjugates showed remarkable reduction in ulcerogenicity compared to parent flurbiprofen. |
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Bibliography: | 0031-7144(20030601)58:6L.389;1- |
ISSN: | 0031-7144 |