Metallic glass nanofibers in future hydrogel-based scaffolds

• Published in: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2014; pp. 5276 - 5279
• Main Authors: Sadeghian, Ramin Banan, Ahadian, Samad, Yaginuma, Shin, Ramon-Azcon, Javier, Liang, Xiaobin, Nakajima, Ken, Shiku, Hitoshi, Matsue, Tomokazu, Nakayama, Koji S., Khademhosseini, Ali
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2014
• Subjects: Adhesives; Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Cell Line; Cell Survival - drug effects; Conductive hydrogel scaffolds; Conductivity; Elastic Modulus; Electrodes; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Gelatin - chemistry; Glass; Glass - chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry; Metallic glass nanofibers; Methacrylated gelatin; Mice; Muscles; Myoblasts - cytology; Myoblasts - metabolism; Nanofibers - chemistry; Optical fiber devices; Palladium - chemistry
• ISSN: 1094-687X; 1557-170X; 1558-4615
• DOI: 10.1109/EMBC.2014.6944816

Electrically conductive reinforced hydrogels offer a wide range of applications as three-dimensional scaffolds in tissue engineering. We report electrical and mechanical characterization of methacrylated gelatin (GelMA) hydrogel, containing palladium-based metallic glass nanofibers (MGNF). Also we show that the fibers are biocompatible and C2C12 myoblasts in particular, planted into the hybrid hydrogel, tend to attach to and elongate along the fibers. The MGNFs in this work were created by gas atomization. Ravel of fibers were embedded in the GelMA prepolymer in two different concentrations (0.5 and 1.0 mg/ml), and then the ensemble was cured under UV light, forming the hybrid hydrogel. The conductivity of the hybrid hydrogel was proportional to the fiber concentration.