Automated Multiplexed Potentiostat System (AMPS) for High-Throughput Characterization of Neural Interfaces

Neural interfaces with increasing channel counts require a scalable means of testing. While multiplexed poten-tiostats have long been the solution to this problem, most have been dedicated to one specific probe design or potentiostat, limited in the electrochemical techniques available, inordinately...

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Bibliographic Details
Published in2021 IEEE Biomedical Circuits and Systems Conference (BioCAS) Vol. 2021; pp. 01 - 05
Main Authors Massey, Travis L., Gleick, Jeremy R., Haque, Razi-ul M.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.10.2021
Subjects
Impedance measurement
In vivo
Microelectrodes
Microfabrication
Multiplexing
Philosophical considerations
Surface impedance
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Summary:Neural interfaces with increasing channel counts require a scalable means of testing. While multiplexed poten-tiostats have long been the solution to this problem, most have been dedicated to one specific probe design or potentiostat, limited in the electrochemical techniques available, inordinately expensive, or they support multiplexing of too few channels. We present the design of an automated multiplexed potentiostat system that addresses these limitations-it is easily generalizable to any probe and potentiostat, supports any electrochemical technique available with the potentiostat, is low-cost, and can readily be expanded to hundreds of channels with support for multiple simultaneous potentiostats. This paper discusses the design philosophy and architecture of our 512-channel, 4-potentiostat system before demonstrating functionality with electrochemical impedance spectroscopy data, cyclic voltammetry curves, and an example of electrochemical surface modification, all on functional implantable microelectrode arrays currently being used for in vivo electrophysiological studies. Finally, we discuss the limitations to some sensitive or high-frequency impedance measurements due to reactive parasitics. Clinical relevance- Microscale thin-film neural interfaces with hundreds of channels are being developed by many research groups using advanced microfabrication techniques. Scalable, high-throughput characterization of these devices prior to surgical implantation increases confidence in their efficacy. This reduces risk to the patient associated with extended or repeat surgeries to replace a poorly functioning electrode array.
DOI:10.1109/BioCAS49922.2021.9644948