Prevalence of antimicrobial drug-resistant Streptococcus pneumoniae in Washington State

• Published in: The Western journal of medicine Vol. 169; no. 6; pp. 364 - 369
• Main Authors: Frick, P A, Black, D J, Duchin, J S, Deliganis, S, McKee, W M, Fritsche, T R
• Format: Journal Article
• Language: English
• Published: United States BMJ Publishing Group LTD 01.12.1998
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Ceftriaxone - therapeutic use; Cephalosporin Resistance; Cephalosporins - therapeutic use; Child; Child, Preschool; Drug Resistance, Microbial; Erythromycin - therapeutic use; Female; Humans; Imipenem - therapeutic use; Infant; Male; Middle Aged; Penicillin Resistance; Pneumococcal Infections - drug therapy; Prevalence; Risk Factors; Serotyping; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - drug effects; Thienamycins - therapeutic use; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use; USA, Washington; Washington; Washington
• ISSN: 0093-0415; 1476-2978

We conducted a survey to assess the prevalence and geographic distribution of antimicrobial drug resistance among invasive isolates of Streptococcus pneumoniae in Washington State. Sequential sterile-site pneumococcal isolates were submitted from 13 hospital laboratories between 1 October 1995 and 30 January 1997. We serotyped 275 isolates from adults and children and determined minimum inhibitory concentrations (MIC) for commonly used antimicrobial drugs. Data were abstracted from medical records to compare differences in outcome and risk factors for infection. Of the 275 isolates, 73 (26.5%) were nonsusceptible to one or more antimicrobial drugs. Penicillin-nonsusceptible pneumococci (PNSP, MIC > or = 0.1 microgram/ml) accounted for 42 (15.3%) of the 275 isolates including 4 (1.5%) resistant strains (MIC > or = 2 micrograms/ml). The 42 PNSP included serogroups 6, 9, 14, 19, and 23, all of which are represented in the 23-valent pneumococcal vaccine. PNSP were also nonsusceptible to trimethoprim/sulfamethoxazole (92.9%), erythromycin (38.1%), imipenem (28.6%), and ceftriaxone (23.8%). Forty-seven (17.1%) of the 275 isolates were multiple drug-nonsusceptible pneumococci (MDNSP). A significantly greater number of patients < or = 12 years of age were infected with MDNSP compared with those > 12 years. Prior use of antimicrobial drugs and an immunosuppressive disorder were risk factors for infection with PNSP. In summary, pneumococci nonsusceptible to penicillin and other antimicrobial drugs are prevalent among adults with invasive pneumococcal disease in Washington State. A large proportion of PNSP are resistant to other commonly used antimicrobial drugs. Local antibiotic susceptibility data should be considered when designing empiric treatment regimens.