A protein which specifically binds to single stranded TTAGGGn repeats

Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomertc terminal repeats, TTAGGG. In some tissues this Is an abundant nuclear protein.

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Bibliographic Details
Published inNucleic acids research Vol. 20; no. 6; pp. 1387 - 1391
Main Authors McKay, Stewart J., Cooke, Howard
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 25.03.1992
Subjects
Analytical, structural and metabolic biochemistry
Animals
Base Sequence
Binding and carrier proteins
Biological and medical sciences
DNA, Single-Stranded - metabolism
DNA-Binding Proteins - isolation & purification
DNA-Binding Proteins - metabolism
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Mice
Molecular Sequence Data
Proteins
Repetitive Sequences, Nucleic Acid
Species Specificity
Telomere - metabolism
Nucleus
Sequence specificity
Vertebrata
Repeated sequence
DNA binding protein
Cell extract
Single stranded DNA
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Summary:Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomertc terminal repeats, TTAGGG. In some tissues this Is an abundant nuclear protein.
Bibliography:ark:/67375/HXZ-QCCXSKLB-5
To whom correspondence should be addressed
istex:F36E9361AFB4F4EB38F0B96D8DFB6B3C67763496
ArticleID:20.6.1387
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/20.6.1387