Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis
The pathogenesis of polymorphic light eruption (PLE) has been linked to a lack of UV‐induced immune suppression. To determine the role of Langerhans cells (LC), mast cells and regulatory T cells, biopsies from PLE patients were taken from exposed sites in spring before and after photohardening with...
Saved in:
Published in | Experimental dermatology Vol. 23; no. 6; pp. 428 - 430 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Blackwell Publishing Ltd
01.06.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The pathogenesis of polymorphic light eruption (PLE) has been linked to a lack of UV‐induced immune suppression. To determine the role of Langerhans cells (LC), mast cells and regulatory T cells, biopsies from PLE patients were taken from exposed sites in spring before and after photohardening with 311 nm or PUVA as well as again in summer. Skin sections were assessed for the presence of Langerin/CD1a+ LC and CD3+, CD4+, CD25+ or FoxP3+ T cells and mast cells. Photohardening transiently decreased the density of epidermal LC and significantly increased a low baseline mast cell density in the papillary dermis of PLE patients. Baseline T cell numbers in the skin were low, and there was no difference in PLE patients among any time point. This suggests that LC suppression together with recruitment of mast cells into photohardened skin may be a key cellular event underlying the mechanism by which phototherapy protects from PLE. |
---|---|
Bibliography: | Oesterreichische Nationalbank Anniversary Fund - No. 13279 FWF Austrian Science Fund - No. KLI 132-B00 istex:CE849987F7BE512F5875EA3A1A403C7B0B810DA7 ArticleID:EXD12427 Data S1. Materials and Methods.Table S1. Results of Langerhans cell and mast cell counts in patients with polymorphic light eruption and healthy control subjects. ark:/67375/WNG-76WP4H95-T SourceType-Other Sources-1 content type line 63 ObjectType-Feature-2 ObjectType-Correspondence-1 ObjectType-Article-3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0906-6705 1600-0625 |
DOI: | 10.1111/exd.12427 |