MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic

• Published in: Environmental and molecular mutagenesis Vol. 56; no. 9; pp. 759 - 766
• Main Authors: Recio-Vega, Rogelio, Dena-Cazares, Jose Angel, Ramirez-de la Peña, Jorge Luis, Jacobo-Ávila, Antonio, Portales-Castanedo, Arnulfo, Gallegos-Arreola, Martha Patricia, Ocampo-Gomez, Guadalupe, Michel-Ramirez, Gladis
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.12.2015; Wiley Subscription Services, Inc
• Subjects: ABCC; Adult; Aged; arsenic; Arsenic - toxicity; Arsenic - urine; BAL; Bronchoalveolar Lavage Fluid; Case-Control Studies; Drinking Water; Environmental Exposure - adverse effects; Female; Humans; Lung cancer; Lung Neoplasms - metabolism; Male; Mexico; Middle Aged; MRP1; Multidrug Resistance-Associated Proteins - metabolism; lung cancer; MRP1; arsenic; BAL; ABCC
• ISSN: 0893-6692; 1098-2280
• DOI: 10.1002/em.21960

Alteration of multidrug resistance‐associated protein‐1 (MRP1) expression has been associated with certain lung diseases, and this protein may be pivotal in protecting the lungs against endogenous or exogenous toxic compounds. The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water. MRP1 expression was assessed in bronchoalveolar cells in a total of 102 participants. MRP1 expression was significantly decreased in those with arsenic urinary levels >50 μg/L when compared with the controls. In conclusion, chronic arsenic exposure negatively correlates with the expression of MRP1 in BAL cells in patients with lung cancer. Environ. Mol. Mutagen. 56:759–766, 2015. © 2015 Wiley Periodicals, Inc.