Involvement of dopamine D1 receptors of the hippocampal dentate gyrus in spatial learning and memory deficits in a rat model of vascular dementia
We investigated the involvement of dopamine (DA) and its D1 receptors of the hippocampal dentate gyrus (DG) in spatial learning and memory deficits in a rat model of vascular dementia (VD) established by permanent bilateral carotid occlusion. Spatial learning and memory abilities of rats were measur...
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Published in | Pharmazie Vol. 69; no. 9; pp. 709 - 710 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Govi-Verlag
01.09.2014
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Subjects | |
Online Access | Get full text |
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Summary: | We investigated the involvement of dopamine (DA) and its D1 receptors of the hippocampal dentate gyrus (DG) in spatial learning and memory deficits in a rat model of vascular dementia (VD) established by permanent bilateral carotid occlusion. Spatial learning and memory abilities of
rats were measured by Morris water maze, and extracellular concentrations of DA in the DG were determined by in vivo microdialysis. The DA concentrations in the DG decreased in the VD rats compared with sham-operated group. Microinjection of SFK38393 (D1 receptor agonist) into the DG
attenuates spatial learning and memory deficits in the VD rats. |
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Bibliography: | 0031-7144(20140910)69:9L.709;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0031-7144 |
DOI: | 10.1691/ph.2014.4602 |