Use of prebiotics in oral delivery of bioactive compounds: a nanotechnology perspective

The oral route is considered the most patient-convenient means of drug administration. In recent years there has been a tendency to employ smart carrier systems that enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects. Nan...

Full description

Saved in:
Bibliographic Details
Published inPharmazie Vol. 66; no. 5; pp. 319 - 324
Main Authors Heidarpour, F, Mohammadabadi, M R, Zaidul, I S M, Maherani, B, Saari, N, Hamid, A A, Abas, F, Manap, M Y A, Mozafari, M R
Format Journal Article
LanguageEnglish
Published Germany Govi-Verlag 01.05.2011
Subjects
Administration, Oral
Animals
Drug Delivery Systems
Fermentation
Humans
Nanotechnology
Pharmaceutical Preparations - administration & dosage
Polysaccharides - chemistry
Prebiotics
Prodrugs - administration & dosage
Tablets, Enteric-Coated
Online AccessGet full text

Cover

More Information
Summary:The oral route is considered the most patient-convenient means of drug administration. In recent years there has been a tendency to employ smart carrier systems that enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects. Nano-encapsulation systems (nanocarriers) offer important advantages over conventional drug delivery techniques. Nanocarriers can protect the drug from chemical/enzymatic degradation and enhance bioavailability. Prebiotics are ideal ingredients for the nano-encapsulation and oral drug delivery due to their natural ability to protect the encapsulated compound in the upper gasterointestinal (GI) tract. Here the potential of prebiotics for oral delivery of drugs and other bioactives is reviewed.
Bibliography:0031-7144(20110510)66:5L.319;1-
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0031-7144
DOI:10.1691/ph.2011.0279