Studies of the skin permeation of lipophilic drugs: paclitaxel

The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.

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Bibliographic Details
Published inPharmazie Vol. 62; no. 6; pp. 471 - 473
Main Authors Khandavilli, S., Panchagnula, R.
Format Journal Article
LanguageEnglish
Published Germany Govi-Verlag 01.06.2007
Subjects
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacokinetics
Diffusion Chambers, Culture
Ethanol
In Vitro Techniques
Lipids - chemistry
Paclitaxel - administration & dosage
Paclitaxel - chemistry
Paclitaxel - pharmacokinetics
Permeability
Pharmaceutical Vehicles
Rats
Rats, Sprague-Dawley
Skin Absorption
Water Loss, Insensible
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Summary:The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.
Bibliography:0031-7144(20070601)62:6L.471;1-
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ISSN:0031-7144
DOI:10.1691/ph.2007.6.6044