Effect of charge and size of diffusing probe on the diffusion through calcium alginate gel matrices

The diffusion of latex particles and low molecular weight fluorescein analogues in homogenous, well-defined calcium alginate gel matrices was studied. The experimental results indicate that the different types of diffusion probes are retarded by different mechanisms in the gel. The positively charge...

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Bibliographic Details
Published inPharmazie Vol. 62; no. 12; pp. 914 - 918
Main Authors Holte, Ø., Tønnesen, H. H., Karlsen, J.
Format Journal Article
LanguageEnglish
Published Germany Govi-Verlag 01.12.2007
Subjects
Alginates - chemistry
Algorithms
Chemical Phenomena
Chemistry, Physical
Coloring Agents
Data Interpretation, Statistical
Diffusion
Fluorescein
Gels - chemistry
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Latex
Molecular Weight
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ISSN0031-7144
DOI10.1691/ph.2007.12.6037

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Summary:The diffusion of latex particles and low molecular weight fluorescein analogues in homogenous, well-defined calcium alginate gel matrices was studied. The experimental results indicate that the different types of diffusion probes are retarded by different mechanisms in the gel. The positively charged low molecular weight substance experienced some degree of retardation by the gels, but the diffusion rate of the uncharged low molecular weight substance was little influenced by gel composition. A wide range of diffusion rates was observed for the particles in the various gel compositions.
Bibliography:0031-7144(20071201)62:12L.914;1-
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ISSN:0031-7144
DOI:10.1691/ph.2007.12.6037