New benzoyl urea derivatives as novel NR2B selective NMDA receptor antagonists

A novel series of benzoyl urea derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substitution of the piperidine ring on the biological activity of the compounds was studied. Compound 9 was active in the formalin test in mice.

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Bibliographic Details
Published inPharmazie Vol. 61; no. 9; pp. 799 - 800
Main Authors Borza, I., Greiner, I., Kolok, S., Galgóczy, K., Ignácz-Szendrei, Gy, Horváth, Cs, Farkas, S., Gáti, T., Háda, V., Domány, Gy
Format Journal Article
LanguageEnglish
Published ESCHBORN Govi-Verlag 01.09.2006
Govi-Verlag Pharmazeutischer Verlag Gmbh
Subjects
Benzoates - chemical synthesis
Benzoates - pharmacology
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Chromatography, High Pressure Liquid
Fluorometry
Formaldehyde
Indicators and Reagents
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Mass Spectrometry
Pain Measurement - drug effects
Pharmacology & Pharmacy
Physical Sciences
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Science & Technology
Spectrophotometry, Infrared
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - pharmacology
SUBUNIT
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Summary:A novel series of benzoyl urea derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substitution of the piperidine ring on the biological activity of the compounds was studied. Compound 9 was active in the formalin test in mice.
Bibliography:0031-7144(20060901)61:9L.799;1-
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ISSN:0031-7144