Synthesis and anti-inflammatory effect of lipophilic derivatives of threo-DL-phenylserine in rat experimental edema

Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 2...

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Bibliographic Details
Published inPharmazie Vol. 59; no. 4; pp. 321 - 323
Main Authors Dirvianskytė, N., Leonavičienė, L., Bradūnaitė, R., Razumas, V., Butkus, E.
Format Journal Article
LanguageEnglish
Published ESCHBORN Govi-Verlag 01.04.2004
Govi-Verlag Pharmazeutischer Verlag Gmbh
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Carrageenan
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Edema - chemically induced
Edema - drug therapy
Edema - pathology
Foot - pathology
Indicators and Reagents
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Male
Pharmacology & Pharmacy
Physical Sciences
Rats
Rats, Wistar
Science & Technology
Serine - analogs & derivatives
Serine - chemical synthesis
Serine - pharmacology
Spectrophotometry, Infrared
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Summary:Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.
Bibliography:0031-7144(20040401)59:4L.321;1-
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ISSN:0031-7144