Dynamic QT/RR Coupling in Patients with Pacemakers
The dynamic coupling between heart rate intervals (RR) and ventricular repolarization (QT) is analyzed. The analysis is based on measurements of 11 patients with pacemaker. In each measurement, there are at least 4 abrupt changes of RR preset by the pacemaker. With such a protocol, RR changes are im...
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Published in | 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2007; pp. 919 - 922 |
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Main Authors | , , , , , , , , |
Format | Conference Proceeding Journal Article |
Language | English |
Published |
United States
IEEE
01.01.2007
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Subjects | |
Online Access | Get full text |
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Summary: | The dynamic coupling between heart rate intervals (RR) and ventricular repolarization (QT) is analyzed. The analysis is based on measurements of 11 patients with pacemaker. In each measurement, there are at least 4 abrupt changes of RR preset by the pacemaker. With such a protocol, RR changes are important and well defined while disturbing factors and noise sources (such as those related with motion of patient) are minimized. The QT/RR coupling was described by 3 parameters (a 1 , b 2 , b 3 ) transfer function (TRF) selected on the basis of a statistical analysis of performances of different TRF models. We found that our model is by far the best in its class: with more parameters (higher order models) the residuals remain almost the same while the extra parameters display variability much larger than that of our parameters. For all measurements, our TRF model describes more than 70 % of QT variability. Within the patient set, we found interesting differences concerning dynamic non-linearity (response times longer with decreasing RR intervals than with increasing RR). |
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ISBN: | 9781424407873 1424407877 |
ISSN: | 1094-687X 1557-170X 1558-4615 |
DOI: | 10.1109/IEMBS.2007.4352441 |