Bredemeyeroside D, a Novel Triterpenoid Saponin from Bredemeyera floribunda: A Potent Snake Venom Antidote Activity on Mice

• Published in: Phytotherapy research Vol. 10; no. 8; pp. 666 - 669
• Main Authors: Pereira, Bettina Monika Ruppelt, Daros, Maria do Rosário, Parente, José Paz, Matos, Francisco José de Abreu
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.1996; Wiley
• Subjects: bidesmosidic triterpenoid glycoside; Biological and medical sciences; Bredemeyera floribunda; bredemeyeroside D; General pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Polygalaceae; snake venom; South America; Brazil; America; Terpenoid; Root; Polygalaceae; Rodentia; Oral administration; Ophidia; Saponin; Prevention; Vertebrata; Mammalia; Folk medicine; Mouse; Dicotyledones; Animal; Venom; Angiospermae; Plant origin; Triterpene; Isolation; Reptilia; Spermatophyta; Phytotherapy; Antidote; Structural analysis
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/(SICI)1099-1573(199612)10:8<666::AID-PTR937>3.0.CO;2-H

A new triterpenoid saponin named bredemeyeroside D has been isolated from Bredemeyera floribunda Willd. and its structure elucidated as 3‐O‐β‐D‐glucopyranosyl‐2β,3β,27‐trihydroxyolean‐12‐en‐23,28‐dioic acid 28‐O‐β‐D‐xylopyranosyl ‐ (1−4) ‐ α ‐ L ‐ rhamnopyranosyl ‐ (1→2) ‐ [α ‐ L ‐ rhamnopyranosyl ‐ (1→3)] ‐ β ‐ D ‐ fucopyranoside by means of MS, NMR and chemical evidences. In laboratory testings bredemeyeroside D showed a significant snake venom antidote activity.