Long-term neuropsychological effects and MRI findings in patients with CS2 poisoning

• Published in: Acta neurologica Scandinavica Vol. 106; no. 5; pp. 269 - 275
• Main Authors: Cho, S. K., Kim, R. H., Yim, S. H., Tak, S. W., Lee, Y. K., Son, M. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.11.2002; Blackwell
• Subjects: Aged; Behavioral Symptoms - chemically induced; Behavioral Symptoms - pathology; Biological and medical sciences; Brain Infarction - chemically induced; Brain Infarction - pathology; carbon disulfide; Carbon Disulfide - administration & dosage; Carbon Disulfide - poisoning; Chemical and industrial products toxicology. Toxic occupational diseases; Dose-Response Relationship, Drug; Gas, fumes; Humans; Intelligence Tests; Magnetic Resonance Imaging; Medical sciences; Middle Aged; Nervous System Diseases - chemically induced; Nervous System Diseases - pathology; neuropsychological effects; Occupational Diseases - chemically induced; Occupational Diseases - pathology; Occupational Exposure - adverse effects; Retrospective Studies; Time Factors; Toxicology; Tropical medicine; Human; Performance evaluation; Insecticide; Occupational disease; Pesticides; Fumigant; Psychometrics; Nuclear magnetic resonance imaging; Long term; Carbon disulfide; Medical imagery; Adult; Evolution; Poisoning; Occupational medicine; Intelligence quotient
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1034/j.1600-0404.2002.01245.x

Cho SK, Kim RH, Yim SH, Tak SW, Lee YK, Son MA. Long‐term neuropsychological effects and MRI findings in patients with CS2 poisoning. Acta Neurol Scand 2002; 106:269–275. © Blackwell Munksgaard 2002. Objectives– To evaluate the long‐term neuropsychological effects and magnetic resonance imaging (MRI) findings among retired patients with a history of exposure to carbon disulfide (CS2). Material and methods– Seventy‐four patients with a history of exposure to CS2 were divided into two equal groups according to their level of exposure, and they completed a questionnaire and were evaluated for neuropsychological symptoms using the Korean version of the revised Wechsler Adult Intelligence Scale. Thirty‐one MRI images were reviewed retrospectively. Results– There were no statistically significant differences in total, verbal and performance IQs between high‐ and low‐exposure groups. MRI findings revealed a significantly larger number of cerebral lacunae (five of 12 subjects) in the high‐exposure group. Periventricular hyperintensities were mostly located in frontal and occipital areas, and white‐matter hyperintensities were mostly in frontal and parietal areas. Conclusion– The higher prevalence of lacunae in the high‐exposure group as revealed by MRI suggests that further MRI studies are needed into long‐term neuropsychological effects induced by CS2.