Benzophenanthridine Alkaloids from Zanthoxylum nitidum (Roxb.) DC, and Their Analgesic and Anti-Inflammatory Activities

• Published in: Chemistry & biodiversity Vol. 3; no. 9; pp. 990 - 995
• Main Authors: Hu, Jiang, Zhang, Wei-Dong, Liu, Run-Hui, Zhang, Chuan, Shen, Yun-Heng, Li, Hui-Liang, Liang, Ming-Jin, Xu, Xi-Ke
• Format: Journal Article
• Language: English
• Published: Zürich WILEY-VCH Verlag 01.09.2006; WILEY‐VCH Verlag
• Subjects: Alkaloids; Analgesic activity; Animals; Anti-inflammatory activity; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Benzophenanthridine alkaloids; Benzophenanthridines - chemistry; Benzophenanthridines - isolation & purification; Benzophenanthridines - therapeutic use; Edema - drug therapy; Male; Mice; Molecular Structure; Pain - drug therapy; Plant Roots - chemistry; Structure-Activity Relationship; Zanthoxylum; Zanthoxylum - chemistry; Zanthoxylum nitidum
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.200690108

Seven benzophenanthridine alkaloids, 1–7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)‐8‐[(R)‐1‐hydroxyethyl]dihydrochelerythrine (1) and 8‐methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8‐methoxychelerythrine (6), and 8‐hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti‐inflammatory effects as hydrocortisone.