Differential Antibiotic Excretion in Unilateral Structural Pyelonephritis

Differential antibiotic excretion studies in eight patients with unilateral structural pyelonephritis showed that in all instances there was impairment in antibiotic excretion on the affected side compared with the normal kidney. Both peak and mean urinary concentrations were decreased on the struct...

Full description

Saved in:
Bibliographic Details
Published inThe Western journal of medicine Vol. 120; no. 5; pp. 363 - 368
Main Author Palmer, J M
Format Journal Article
LanguageEnglish
Published United States BMJ Publishing Group LTD 01.05.1974
Subjects
Cephaloglycin - metabolism
Female
Humans
Kidney - metabolism
Kidney Concentrating Ability
Nalidixic Acid - metabolism
Penicillin G - metabolism
Pyelonephritis - metabolism
Online AccessGet full text

Cover

More Information
Summary:Differential antibiotic excretion studies in eight patients with unilateral structural pyelonephritis showed that in all instances there was impairment in antibiotic excretion on the affected side compared with the normal kidney. Both peak and mean urinary concentrations were decreased on the structurally abnormal side. The degree of defect in antibiotic concentration was proportional to the amount of unilateral medullary damage, as measured by differential renal function studies. While the antibiotic concentrations achieved had an inconsistent relationship to cure in three patients with proven unilateral infections, the striking decreases in urinary antibiotic levels may argue against oral penicillin-G treatment of unilateral pyelonephritis in which there is renal parenchymal damage. Images
Bibliography:istex:CF1D6BEDCE7E6FC84E4D92DB43A19280EDF2968F
PMID:4839481
ark:/67375/NVC-B38HD75K-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0093-0415
1476-2978