Effects of variation in systemic blood pressure on intraosseous pressure, PO2, and PCO2

Several regulatory mechanisms have been shown to influence the intraosseous circulation. The influence of general hypovolemia on bone circulation and possible regulatory effects were investigated by recording the intraosseous pressure and PO2 and PCO2 continuously by mass spectrometry in rabbits. Hy...

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Bibliographic Details
Published inJournal of orthopaedic research Vol. 8; no. 4; p. 618
Main Authors Kiaer, T, Grønlund, J, Jensen, B, Svalastoga, E
Format Journal Article
LanguageEnglish
Published United States 01.07.1990
Subjects
Animals
Blood Circulation - physiology
Blood Gas Analysis
Blood Pressure - physiology
Bone and Bones - blood supply
Bone and Bones - physiology
Carbon Dioxide - physiology
Oxygen - physiology
Partial Pressure
Rabbits
Regional Blood Flow
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Summary:Several regulatory mechanisms have been shown to influence the intraosseous circulation. The influence of general hypovolemia on bone circulation and possible regulatory effects were investigated by recording the intraosseous pressure and PO2 and PCO2 continuously by mass spectrometry in rabbits. Hypovolemia was induced by repeated bleedings. The intraosseous and arterial pressures were found to be linearly related. The intraosseous PO2 already decreased after the first step of bleeding and decreased more than 50% of the initial value after an average blood loss of 40 ml. The intraosseous PCO2 showed an opposite pattern. The experimental PO2 vs. arterial pressure curves were similar to curves obtained by a computer simulation that assumes the blood flow to be proportional to the intraosseous pressure.
ISSN:0736-0266
DOI:10.1002/jor.1100080419