Physicochemical and analytical characteristics of amiodarone

Data are reported on the analytical and physicochemical characteristics of amiodarone, for use in identifying and/or assaying this antiarrhythmic agent. The drug is highly soluble in chloroform and poorly soluble in water. Its acid-base constant (pKa) is 6.56, and its maximal lipid solubility range...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 73; no. 6; p. 829
Main Authors Bonati, M, Gaspari, F, D'Aranno, V, Benfenati, E, Neyroz, P, Galletti, F, Tognoni, G
Format Journal Article
LanguageEnglish
Published United States 01.06.1984
Subjects
Amiodarone - analysis
Benzofurans - analysis
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid - methods
Hydrogen-Ion Concentration
Mass Spectrometry - methods
Solubility
Solvents
Spectrophotometry, Infrared - methods
Spectrophotometry, Ultraviolet - methods
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Summary:Data are reported on the analytical and physicochemical characteristics of amiodarone, for use in identifying and/or assaying this antiarrhythmic agent. The drug is highly soluble in chloroform and poorly soluble in water. Its acid-base constant (pKa) is 6.56, and its maximal lipid solubility range is from pH 3.5 to 5.5.
ISSN:0022-3549
DOI:10.1002/jps.2600730632