Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands

Ground out: Mechanochemical methods gave the pharmaceutical ingredient bismuth subsalicylate, as well as bismuth disalicylate and trisalicylate directly from bismuth oxide. Structure determination by powder X‐ray diffraction gave the first structure of a bismuth salicylate without auxiliary organic...

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Published inAngewandte Chemie International Edition Vol. 50; no. 34; pp. 7858 - 7861
Main Authors André, Vânia, Hardeman, Andrew, Halasz, Ivan, Stein, Robin S., Jackson, Graham J., Reid, David G., Duer, Melinda J., Curfs, Caroline, Duarte, M. Teresa, Friščić, Tomislav
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.08.2011
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
bismuth
Bismuth - chemistry
Chemistry Techniques, Synthetic
Crystallography, X-Ray
Ligands
Magnetic Resonance Spectroscopy
mechanochemistry
metallodrugs
Models, Molecular
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Salicylates - chemical synthesis
Salicylates - chemistry
structure elucidation
sustainable chemistry
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Summary:Ground out: Mechanochemical methods gave the pharmaceutical ingredient bismuth subsalicylate, as well as bismuth disalicylate and trisalicylate directly from bismuth oxide. Structure determination by powder X‐ray diffraction gave the first structure of a bismuth salicylate without auxiliary organic ligands (see picture: Bi yellow, O red, C gray, two salicylate ion coordination modes are shown in purple and green).
Bibliography:Herchel Smith fund is acknowledged for funding and a research fellowship (T.F.) and the BBSRC for financial support (D.G.R.). G.J.J. acknowledges a SA/UK Science Networks grant from the British Council administered by the RSC. V.A. acknowledges Fundação para a Ciência e a Tecnologia for funding (SFRH/BD/40474/2007). Dr. J. E. Davies is acknowledged for single-crystal diffraction data. Prof. R. E. Dinnebier is acknowledged for support in structure determination from powder diffraction data and Andy Fitch, ESRF, for support in synchrotron data collection.
BBSRC
SA/UK Science Networks grant from the British Council administered by the RSC
istex:D701BB5B63C91EE8886F44BF1450386354CA94E1
Fundação para a Ciência e a Tecnologia - No. SFRH/BD/40474/2007
ArticleID:ANIE201103171
Herchel Smith fund
ark:/67375/WNG-Z5GNBG5N-2
Herchel Smith fund is acknowledged for funding and a research fellowship (T.F.) and the BBSRC for financial support (D.G.R.). G.J.J. acknowledges a SA/UK Science Networks grant from the British Council administered by the RSC. V.A. acknowledges Fundação para a Ciência e a Tecnologia for funding (SFRH/BD/40474/2007). Dr. J. E. Davies is acknowledged for single‐crystal diffraction data. Prof. R. E. Dinnebier is acknowledged for support in structure determination from powder diffraction data and Andy Fitch, ESRF, for support in synchrotron data collection.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201103171