Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy

• Published in: Histopathology Vol. 68; no. 5; pp. 673 - 679
• Main Authors: Kim, Sung Han, Park, Weon Seo, Yun, Soo In, Joo, Jungnam, Joung, Jae Young, Seo, Ho Kyung, Chung, Jinsoo, Lee, Geon Kook, Lee, Kang Hyun
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; biochemical recurrence; BRCA; BRCA1 Protein - metabolism; BRCA2 Protein - metabolism; Breast cancer; Disease-Free Survival; Humans; Immunohistochemistry; Male; Medical prognosis; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasm Recurrence, Local; Predictive Value of Tests; Prognosis; Prostate - metabolism; Prostate - pathology; Prostate cancer; Prostatectomy; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; radical prostatectomy; tissue microarray; BRCA; prostate cancer; radical prostatectomy; immunohistochemistry; biochemical recurrence; tissue microarray
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/his.12809

Aims To investigate the protein expressions of breast cancer 1 (BRCA1) and 2 (BRCA2) in prostatectomy specimens of localized prostate cancer (PC) patients, along with their associations with cancer characteristics and prognosis. Methods and results Immunohistochemistry for BRCA1 and BRCA2 was performed on tissue microarrays of 510 PC cases treated from 2002 to 2012. The cytoplasmic immunoreactivity was scored for intensity, and clinicopathological parameters, including biochemical recurrence (BCR), were evaluated. During a median follow‐up of 44 months, 128 patients developed BCR, with positive staining rates of 93.3% (n = 476) and 41.6% (n = 212) for BRCA1 and BRCA2, respectively, in the malignant tissues. The BRCA2 expression differed significantly between BCR‐positive and BCR‐free cases [hazard ratio (HR): 1.75, P = 0.002]. BRCA1 and BRCA2 correlated significantly with age [odds ratio (OR): 0.131] and pN stage (OR: 6.00), pN stage (OR: 1.717) and BCR (OR: 1.972), respectively (P < 0.05). Multivariate analysis showed that BRCA1 (HR: 0.435), BRCA2 (HR: 2.45), pT3 stage (HR: 2.253), resection margin positivity (HR: 1.58), prostate size (HR: 0.975) and Gleason score (HR: 2.214–2.253) were independent predictors of BCR (P < 0.05). Moreover, BRCA2 correlated significantly with BCR‐free survival (P = 0.0017). Conclusions BRCA1 or BRCA2 overexpression is a significant predictive factor for BCR in PC patients.