Body composition and outcome in patients undergoing resection of colorectal liver metastases

• Published in: British journal of surgery Vol. 99; no. 4; pp. 550 - 557
• Main Authors: van Vledder, M. G., Levolger, S., Ayez, N., Verhoef, C., Tran, T. C. K., IJzermans, J. N. M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2012; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Body Composition - physiology; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Hepatectomy - methods; Humans; Intra-Abdominal Fat - pathology; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Muscle, Skeletal - pathology; Neoplasm Recurrence, Local; Obesity, Abdominal - complications; Obesity, Abdominal - pathology; Prospective Studies; Sarcopenia - complications; Sarcopenia - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome; Tumors; Human; Rectal disease; Prognosis; Colorectal cancer; Hepatic disease; Patient; Surgical resection; Malignant tumor; Body composition; Colonic disease; Medicine; Treatment; Surgery; Digestive diseases; Intestinal disease; Evolution; Liver metastasis; Cancer
• ISSN: 0007-1323; 1365-2168
• DOI: 10.1002/bjs.7823

Background: Recent evidence suggests that depletion of skeletal muscle mass (sarcopenia) and an increased amount of intra‐abdominal fat (central obesity) influence cancer statistics. This study investigated the impact of sarcopenia and central obesity on survival in patients undergoing liver resection for colorectal liver metastases (CLM). Methods: Diagnostic imaging from patients who had hepatic resection for CLM in one centre between 2001 and 2009, and who had assessable perioperative computed tomograms, was analysed retrospectively. Total cross‐sectional areas of skeletal muscle and intra‐abdominal fat, and their influence on outcome, were analysed. Results: Of the 196 patients included in the study, 38 (19·4 per cent) were classified as having sarcopenia. Five‐year disease‐free (15 per cent versus 28·5 per cent in patients without sarcopenia; P = 0·002) and overall (20 per cent versus 49·9 per cent respectively; P < 0·001) survival rates were lower for patients with sarcopenia at a median follow‐up of 29 (range 1–97) months. Sarcopenia was an independent predictor of worse recurrence‐free (hazard ratio (HR) 1·88, 95 per cent confidence interval 1·25 to 2·82; P = 0·002) and overall (HR 2·53, 1·60 to 4·01; P < 0·001) survival. Central obesity was associated with an increased risk of recurrence in men (P = 0·032), but not in women (P = 0·712). Conclusion: Sarcopenia has a negative impact on cancer outcomes following resection of CLM. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Muscle wasting bad