Protective Effects of Aucubin on H2O2-Induced Apoptosis in PC12 Cells

• Published in: Phytotherapy research Vol. 26; no. 3; pp. 369 - 374
• Main Authors: Xue, Hong-Yu, Gao, Gui-Zhen, Lin, Qiu-Ye, Jin, Li-Ji, Xu, Yong-Ping
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2012; Wiley
• Subjects: Animals; Antioxidants - metabolism; Apoptosis; aucubin; Biological and medical sciences; Catalase - metabolism; Cell Nucleus Shape; Cell Survival; Enzyme Activation; Flow Cytometry; General pharmacology; Glutathione Peroxidase - metabolism; hydrogen peroxide; Hydrogen Peroxide - adverse effects; Hydrogen Peroxide - metabolism; Iridoid Glucosides - pharmacology; L-Lactate Dehydrogenase - metabolism; Malondialdehyde - metabolism; Medical sciences; Neuroprotective Agents - pharmacology; oxidant-antioxidant balance; Oxidative Stress; PC12 Cells; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rats; Staining and Labeling; Superoxide Dismutase - metabolism; Iridoid; Terpenoid; Hydrogen peroxide; Pharmacognosy; oxidant―antioxidant balance; Antioxidant; aucubin; In vitro; PC12 cells; Medicinal plant; Prevention; Cell death; Plant origin; Monoterpene; Glycoside; Apoptosis

The present study investigated the neuroprotective effects of aucubin on hydrogen peroxide (H2O2)‐induced apoptosis in PC12 cells. Exposure of PC12 cells to 0.25 mm H2O2 induced a leakage of lactate dehydrogenase and decreased cell viability, as shown by 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenylte...